News

DSC: a multifunctional activator in peptide chemistry and drug synthesis

30/8/2024

N, N'-disuccinimidyl carbonate (DSC) is a multifunctional reagent for the preparation of active esters and a substitute for phosgene in various nucleophilic reactions. DSC is sensitive to moisture and will rapidly hydrolyze to release carbon dioxide...

Methyleneamine ylide-mediated [3+2] cycloaddition: the central role of N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine

21/8/2024

Nitrogen-containing heterocyclic compounds are an important class of heterocyclic compounds, and they occupy an important position in the field of organic chemistry. In the field of medicine, nitrogen heterocyclic compounds constitute the core...

Exploring the unique properties and diversified applications of TPS-Cl

26/7/2024

Sulfonyl chloride derivatives play multiple roles in chemistry and biology and have been the subject of extensive interest and research due to their unique chemical properties. They are key intermediates in many drugs, covering a wide range of...

Phosphatidylserine: dual applications in medicine and nutrition

15/6/2024

In eukaryotic cells, the distribution of lipids across biological membranes is asymmetrical. Specifically, sphingolipids, sphingomyelins, and phosphatidylcholine are predominantly distributed on the outside of the cell membrane. In contrast,...

Introduction to Unnatural Amino Acids

17/5/2024

Proteins are important components of living organisms and play an indispensable role in maintaining the normal physiological functions of cells. They are composed of amino acids, the basic building blocks, arranged in a specific sequence. 20 basic...

TCFH - a powerful condensation reagent

19/4/2024

In organic synthesis, an acid-amine condensation reaction is a common chemical transformation, in which amide bonds are common in many natural substances and synthetic materials and constitute the core functional groups of many drug molecules and...

The golden combination of efficient acid-amine condensation: TCFH-NMI

19/4/2024

Acylation reaction is a common type of reaction in organic synthesis. It is a basic reaction for constructing compounds such as amides and esters. Among the many acylation reactions, condensation reagents are particularly common, especially in the...

Protecting groups in organic synthesis - protection and deprotection of alcoholic hydroxyl groups (II)

29/3/2024

In the previous article, we discussed the application of ether-protecting groups in protecting hydroxyl groups. This article will further discuss the hydroxyl protection strategy, mainly including the application of ester-protecting groups and the...

Protecting groups in organic synthesis - protection and deprotection of alcoholic hydroxyl groups (I)

25/3/2024

In organic synthesis, we often encounter multiple functional groups in a compound, but we only want a certain functional group to react. Based on the principles of efficiency and simplicity, it is perfect to find suitable conditions for one-step...

A brief discussion on peptide synthesis methods

1/3/2024

In recent years, with the establishment of solid phase synthesis, gene recombination technology and new chemical modification methods, the synthesis of peptides and the development of peptide drugs have been greatly promoted. Currently, peptide drugs...

A new type of highly efficient, non-racemic alkyne amide condensation reagent

26/1/2024

The formation of amide bonds is a very important reaction in synthetic chemistry. According to statistics, in the pharmaceutical chemistry industry, the construction of amide bonds is the most widely used chemical reaction, accounting for about 25%...

In vitro diagnostic reagents - disodium p-nitrophenyl phosphate

28/12/2023

Commonly used condensation agent reaction mechanism and by-products

10/8/2023

Condensing agents are widely used. With the development of pharmaceutical industry, polypeptide reagents, proteins and polymer materials, condensing agents are used more and more in organic synthesis, and the demand is also increasing year by year.

IPO and listed on Shenzhen Stock Exchange

12/7/2023

Stock abbreviation: Highfine Biotech; stock code: 301393.

What should be considered when choosing a phospholipid?

28/4/2023

When choosing phospholipids, many factors should be considered, such as phase transition temperature, stability, charge, etc., which are explained in detail in this paper.

Application of biotinylated reagents NHS-LC biotin and sulfo-NHS-LC biotin in a new intravascular drug delivery method

14/4/2023

In this study, biotinylation of living endothelial cells was investigated to develop a method to deliver therapeutic drugs to the target area and to anchor the drug to the vascular endothelial cells in the area.

Phase transition temperature of common liposome reagents and net charge at physiological pH

25/3/2023

This table shows the phase transition temperature and net charge at physiological pH for common liposomal reagents.

A Brief Introduction to Click Chemistry

10/3/2023

Click chemistry refers to a set of efficient, robust, and stereoselective reactions that can exploit simple reaction conditions and readily available starting materials to develop promising building blocks.

Several main types of phospholipid reagents

16/2/2023

Phospholipids, an important component of cell membranes, are versatile excipients for a variety of pharmaceutical applications and are biocompatible, biodegradable, and safe for any route of administration.

Trimethylsilylethanol and its derived protecting reagents

30/1/2023

Trimethylsilyl ethanol is a reagent with a wide range of uses. It can be used as a protective reagent for carboxylic acids, and it is also the main raw material for the synthesis of other related protective reagents.

Introduction of a New Azidation Reagent

16/12/2022

Organic azides are important intermediates for the synthesis of nitrogen-containing compounds. The azide group is stable in most cases, but it exhibits characteristic reactivity under special conditions.

Highfine Biotech was identified as an innovative headquarters enterprise in Suzhou

1/12/2022

Recently, the 2022 annual list of Suzhou headquarters enterprises to be identified was announced. 15 enterprises in the high-tech zone were successfully included in the list, ranking among the top in the city. Haofan Biotech was successfully...

A Fmoc protection reagent: Fmoc-Amox

30/9/2022

​Most peptide synthesis is achieved by solid-phase peptide synthesis using Fmoc or Boc protection methods, however, when Fmoc-OSu is used, due to the formation of dipeptide (or tripeptide) and β-alaninamide impurities, in Introduction of an...

Oxyma and its derivatives

17/9/2022

The amide bond is not only an important structural functional group of natural active compounds, such as various polypeptides and proteins but also an important component of many organic compounds, especially pharmaceuticals. According to statistics,...

Introduction to 2-Chloro-1-Methylpyridine Iodide (CMPI)

3/9/2022

​2-Chloro-1-methylpyridinium iodide, referred to as CMPI, is a commonly used condensation reagent. Its English name is 2-Chloro-1-methylpyridinium Iodide, and its molecular formula is C6H7ClIN. The CAS number is 14338-32-0. It is a light yellow solid...

Application of 4-(tert-butyldimethylsilyl)oxo-1-butanol

26/8/2022

4-(text-butyldimethylsilyl)oxo-1-butanol is a colorless to light yellow oily substance with a CAS number of 87184-99-4. The compound is obtained by single-protecting 1,4-butanediol with TBS, and TBS is used as a hydroxyl-protecting group and is...

Pentafluorophenol and its derivatives

30/7/2022

Pentafluorophenol and its derivatives are important chemical intermediates, which are widely used in the fields of medicine and electronic materials. They are the new drug Sofosbuvir successfully developed by the international pharmaceutical giant...

Triphenylphosphine Catalyzed Amidation of Carboxylic Acids

14/7/2022

There are many ways to synthesize amides, and the method of first activating carboxylic acids is more common, such as first making acid chlorides, acyl imidazoles, acid anhydrides or activated esters, etc., and then reacting with amino compounds to...

Introduction to 2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl)

21/5/2022

2-(Trimethylsilyl) methoxymethyl chloride, referred to as SEM-Cl, is a commonly used protective reagent, the English name is 2-(Trimethylsilyl) methoxymethyl chloride, the molecular formula is C6H15ClOSi, the structural formula is shown in Figure 1,...

Application of N-haloalkylphthalimide compounds

28/4/2022

Heterocyclic compounds play an important role in biological processes, and the main part of organic compounds isolated from nature is composed of nitrogen heterocycles. A large number of data reports have shown that heterocyclic compounds as...

Double BOC protection selective removal method

31/3/2022

Boc group protection is widely used in organic synthesis, and it is also an amino-protecting group widely used in peptide synthesis. Especially in solid-phase synthesis, the Boc group is often used for amino protection. The removal of the Boc group...

Burgess, a mild selective dehydrating reagent

23/3/2022

Burgess reagent (Burgess reagent), that is, methyl N-(triethylsulfamoyl) carbamate, is a kind of internal salt of carbamate, the chemical formula is C8H18N2O4S, the structural formula is shown in the figure, and the molecular weight is 238.3....

HOPO, a racemization inhibitor "out of the circle" due to the new crown drug

2/3/2022

At the end of 2021, Pfizer's new crown oral drug Paxlovid was approved by the US FDA for marketing, which aroused widespread concern. One of the main ingredients of Paxlovid is the 3CL protease inhibitor code-named PF-07321332. PF-07321332 plays an...

Application of Triphosgene in Organic Synthesis

22/2/2022

Solid phosgene, also known as triphosgene. The chemical name is bis (trichloromethyl) carbonate [Bis (trichloromethyl) Carbonate], abbreviated as BTC (structural formula shown in Figure 1) is an ideal substitute for phosgene. Phosgene and diphosgene...

Condensation Acylation of Carboxylic Acids and Amines

10/2/2022

Amides are widely used in chemical synthesis, especially the preparation of amides by condensation acylation, which is frequently used in laboratory synthesis. The reaction of carboxylic acids and amines is an important method for the synthesis of...

Synthesis of Nitrile

25/1/2022

Nitrile is an organic compound formed by linking carbon atoms containing hydrocarbon groups and cyano groups. It is an important drug synthesis intermediate, and the synthesis of nitrile is a very important part of organic synthesis. The nucleophilic...

A Brief Introduction to the Racemization of Amino Acids in Polypeptide Synthesis

12/1/2022

Since Fischer's group completed the first dipeptide molecule synthesis in 1901, peptide synthesis has a history of more than 100 years. With the increasing demand for peptides in the fields of drug development and material chemistry, the research on...

Dibenzyl N,N'-diisopropylphosphoramidite

6/1/2022

Protein phosphorylation plays a very important role in biochemical processes. Enzymes in which phosphate groups are introduced are called kinases, and enzymes in which phosphate groups are removed are called phosphatases. Protein phosphorylation can...

Application of Boc-anhydride

29/12/2021

Boc-acid anhydride is often used as a tert-butoxycarbonyl protecting group in organic synthesis, especially for the protection of amino groups in amino acids [1]. Widely used in the synthesis of various products such as medicine, protein and peptide...

Application of Efficient Catalyst DMAP

22/12/2021

Acylation is one of the most common organic chemical reactions, and the commonly used catalysts for acylation reactions are pyridine and triethylamine. In 1967, Litvinenko et al. found that 4-dimethylaminopyridine (DMAP) was used to catalyze the...

Application of dibromotriphenylphosphine

9/12/2021

Dibromotriphenylphosphine was first used in the synthesis reaction in 1959 to prepare bromide and acid bromide from alcohol and carboxylic acid, and it was also used in the dehydration reaction of amides and oximes to nitriles. Now it has been used...

Introduction and removal of alkyl protecting groups of several common amino groups

21/10/2021

In the previous article, we reviewed the common alkoxy carbonyl amino-protecting groups. This article will review another common amino-protecting group—the alkyl-protecting group. These common protecting groups mainly include trityl (Trt), benzyl...

Introduction and Removal of Several Common Alkoxycarbonyl Protecting Groups

16/10/2021

The alkoxy carbonyl-protecting group is the most commonly used type of amino-protecting group. This article briefly introduces the protection and deprotection methods of the following common alkoxy carbonyl amino protecting groups. These common...

Application of Trimethylsilylethoxycarbonyl (teoc) Protecting Group

8/10/2021

Trimethylsilylethoxycarbonyl (Teoc) differs from Cbz, Boc, Fmoc, and Alloc. It is very stable to acids, most alkalis, and noble metal catalysis. In its presence, Cbz, Boc, Fmoc, Alloc, etc. It can be selectively deprotected; its removal is usually...

Introduction to 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)

27/9/2021

1,8-Diazabicyclo[5.4.0]undec-7-ene, or DBU for short, as a recognized sterically forbidden non-nucleophilic base, has been widely used in organic synthesis. In recent years, it has been found that DBU can also participate in the reaction as an...

Brief Introduction of Synthesis of Amides by Mixed Anhydride Method

2/9/2021

The mixed anhydride method was developed in the early 1950s. Beginning with mixed anhydrides of acylamino acids with diphenylphosphoric acid, followed by mixed anhydrides with dibenzylphosphoric acid, and mixed anhydrides with benzoic acid. When the...